RealTop Disposable Mixing Solution

RealTop Disposable Stirring Solutions provide advanced mixing technology for pharmaceutical ingredients ranging from pharmaceutical intermediates to finished preparations, and can also be used for process preparation, such as buffer and culture medium preparation.

RealTop's integrated one-time mixing solution is economical and operationally efficient, saving valuable process and validation time. Ruituo mixing solutions include disposable mixing bags and dry powder feeding bags. Disposable mixing bags are divided into conventional mixing bags and high-performance mixing bags. The conventional mixing bag includes six volume specifications of 10L, 50L, 100L, 200L, 500L and 1000L. The high-performance mixing bag includes five volume specifications of 100L, 200L, 500L, 1000L and 2000L.

the above two kinds of mixing bags adopt magnetic levitation technology, which completely avoids the generation of particles caused by the friction of bearings or impellers. Depending on your specific application and environment, including sterile docking, from cell culture to final filling, you can configure the appropriate filters, connectors and tubing. Our proven, scalable, direct-to-use system and process technologies reduce the risk of contamination, improve economics and process flexibility, and achieve repeatable results.

RealTop disposable mixer

RealTop disposable mixer series has the best mixing performance and process turnover rate. Each disposable mixing bag includes a magnetic suspension impeller to improve the consistency and efficiency of mixing. Unlike traditional stainless steel mixers, disposable mixers reduce downtime due to CIP, SIP, and cleaning verification. The Ruitoto disposable mixer also has the flexibility to operate and can be up and running in five minutes. Stirring speeds of up to 1000 RPM * meet the requirements of a variety of mixing production. * Depends on agitator size.

Reliable, tough PuRobust film and PureSupply + film

mixing bag can be made of PuRobust or PureSupply + film, while the dry powder dosing bag is made of PureSupply + film.

RealTop disposable process container film series is a high purity, medical grade multi-layer co-extruded film, with high strength, high ductility, excellent air tightness and biocompatibility. The liquid contact layer of the film is made of ultra low density polyethylene (ULDPE). The air barrier layers of the films were all made of polyethylene-vinyl alcohol copolymer (EVOH). The outer layer of the PuRobust film is made of LDPE, and the outer layer of the PureSupply + film is made of nylon.

reduce the risk of contamination	Easy to install and use
reduce downtime due to cleaning validation	closed sterile sampling system for representative sample collection
validation, quality and regulatory support	can efficiently mix the most challenging buffers, media and pharmaceutical ingredients ( high-performance mixing bag is more obvious)
single-use technology to increase the capacity of multi-species parallel facilities	working volumes, from a minimum working volume of approximately 10% to a maximum working volume of 120% , is suitable for flexible and variable processes. ( Depending on specific mixing system type and specifications)

Stir evenly

-mounted bottom-mounted deflectable levitation magnetic impeller provides uniform agitation performance.

No stir bar	Bearingless
No support rod	No mechanical contact

faster process turnaround

RealTop mixing systems are ideal for multi-species facilities with high production requirements. The installation of this disposable mixing bag is very simple and can be completed within 5 minutes. After installation, the operator only needs to turn on the agitator to start mixing, which significantly improves the turnover and productivity of the process.

Safe and sterile, sampling directly from the Ruitto mixing bag

All RealTop mixing bags can be equipped with one or several needle-free sampling bags (depending on the user's process requirements). The closed design allows the user to take samples directly from the mixing bag without the risk of cross-contamination. After the sampling is completed, the separation of the sampling bag from the mixing bag is achieved by means of a sterile pinch-off tool (a sterile break-off ring on the sampling tube is pinched off to form two closed sterile ends).

Ensure optimum mixing performance and reliability

Ensuring optimal mixing performance is critical throughout the user's process development, process scale-up and production. Our expert team provides users with a full range of services to ensure that the user's disposable mixing system has a continuous and trustworthy mixing performance.

Dry powder feeding

RealTop Dry Powder Feeding Bag

unique asymmetric dry powder feeding bag for better powder flow	4 inch port to prevent arching effect
optional volume: 5, 10, 15, 25 L	Optional flushing tank

RealTop dry powder feeding bag can choose flushing function. The flushing function safely and effectively flushes residual powder from the dry powder dosing bag directly into the mixer. This feature also allows the user to safely handle the dry powder dosing bag.

in a wide range of applications in the biopharmaceutical field (e. g. preparation, storage and transportation of formulations, sterile solutions or buffers), the Ruitetop standard components provide a convenient disposable solution. The individual components of these standard components are free of animal origin and are pre-sterilized by gamma radiation before leaving the factory and ready to be used directly in your existing production process.

Specifications

conventional mixing bag	10L, 50L, 100L, 200L, 500L, 1000L
high performance mixing bag	100L, 200L, 500L, 1000L and 2000L
structure material
mixing bag body	PuRobust membrane
Port connector	LDPE
Luer connector	PP
CPC Fitting	PC
Line	Silicone
water stop clamp	POM
impeller	PP, connotation magnet
4 "feeding port	HDPE
TC gasket	Silicone
TC Clamp	Nylon
TC Blind	PP
impeller cup	HDPE

dry powder feeding bag
structure material
Dry powder feeding port	PE
Clamp	Nylon
blind plate	PP
Feeding bag body	PuRobust membrane
volume (L)	5, 10, 15, 25
weight (kg)	5, 10, 15, 25
Feeding port	4 "TC chuck
Flushing port	1/4"

PM series and NM series disposable mixing system

Hardware specifications cover 10L-2000L, optional jacket, weighing, temperature, pH, conductivity, pressure, TCU configuration

Features and Advantages

round tank design:
Engineering shape design, to achieve efficient mixing at the same time, avoid the existence of mixing dead.
Eccentric inclined blade:
At the bottom of the mixing motor and paddle for eccentric oblique placement, can provide both radial and axial mixing.
wide door design:
The side of the tank is opened in a large area, which is convenient for the operator to install the mixing bag and reduce the preparation time before use.
Cone bottom liquid:
The bottom of the tank and mixing bag is conical design, and the liquid outlet is located at the lowest point to ensure that the product can be discharged under gravity.
to avoid the loss of valuable products.
10% minimum working volume:
Mixing bags with different volumes have different blade sizes. With the design of conical bottom, the minimum working volume can be as low as about 10% *, avoiding foam during stirring at low liquid level and protecting product activity.

(* depends on specific mixing system type and specifications)

brand hardware:
The key components of the mixing system are Panosonic, Nord, Levitronix, Mettler Toledo,Labom and other brands, with reliable quality and accurate measurement results to ensure the reliability of system operation.
Easy to operate:
Optional touch screen, user can select manual and automatic operation mode in HMI.
Reliable data:
The HMI data recording function generates the original data that cannot be modified, and finally exports it in the form of a report to ensure the true validity of the production record.

model and technical parameters

PM high performance mixing system
Model	volume (L)	stirring speed (rpm)	weighing range (kg)	temperature (C)	pH	conductance (mS/cm)	pressure (bar)
MIX0100PS	100	40-380	0-120	4-60	0-14	0.02-100	0-6
MIX0200PS	200	40-380	0-120	4-60	0-14	0.02-100	0-6
MIX0500PS	500	40-380	0-600	4-60	0-14	0.02-100	0-6
MIX1000PS	1000	40-380	0-1200	4-60	0-14	0.02-100	0-6
MIX2000PS	2000	40-380	0-1200	4-60	0-14	0.02-100	0-6

NM conventional mixing system
Model	volume (L)	stirring speed (rpm)	weighing range (kg)	temperature (C)	pH	conductance (mS/cm)	pressure (bar)
MIX0010NS	10	0-1000	0-20	4-60	0-14	0.02-100	0-6
MIX0050NS	50	0-1000	0-60	4-60	0-14	0.02-100	0-6
MIX0100NS	100	0-500	0-120	4-60	0-14	0.02-100	0-6
MIX0200NS	200	0-500	0-240	4-60	0-14	0.02-100	0-6
MIX0500NS	500	0-250	0-600	4-60	0-14	0.02-100	0-6
MIX1000NS	1000	0-250	0-1200	4-60	0-14	0.02-100	0-6

size/weight estimation and power requirements
volume	length, width and height (cm)	stainless steel without jacket weight (kg)	stainless steel with jacket weight (kg)	Field Power Requirements
10L	11080100	120	180	single phase 220V,10A, National standard three-hole socket
50L	11080100	140	210
100L	11080125	210	315
200L	12090130	275	410
500L	150115150	350	525
1000L	155130190	570	850
2000L	175155215	750	1125

Note: Size and weight vary slightly depending on configuration. Stirring is the default function, weight/temperature/pH/conductivity/pressure and jacket are all optional configurations, and the sensor range can be customized.
① Stirring motor: protection grade IP55
⑤ Pressure: protection grade IP65
② Weighing system: protection grade IP68
The control cabinet: 304 stainless steel, protection grade IP54
③ Temperature: protection grade IP67
⑦ Tank body: 304 stainless steel, Ra≤ 0.8
④ pH/conductivity: protection class IP68

Ordering Information

conventional mixing bag